Sickle Cell Disease: Basic Principles and Clinical Practice

摘要: Written by 80 of the world's foremost basic scientists and clinicians, this volume is first comprehensive reference on sickle cell disease. Because disease has diverse manifestations involves many medical specialties, contributors were chosen for their expertise in specific areas. Their discussions cover virtually every aspect - its molecular cellular biology, pathophysiology, diagnosis, organ-specific complications, clinical management. Coverage begins with recent laboratory findings hemoglobin red pathology. Subsequent sections examine pathophysiology natural history describe diagnostic methods, including prenatal diagnosis neonatal Screening. A major section focuses strategies management complications psychosocial aspects therapy includes antibiotics, transfusion, surgery, patient control, nursing concerns, future prospects cure gene therapy, bone marrow transplantation, drugs that induce fetal haemoglobin synthesis.