Quantification of radiation-induced lung damage with CT scans: The possible benefit for radiogenomics

摘要: AbstractBackground. Radiation-induced lung damage (RILD) is an important problem. Although physical parameters such as the mean dose are used in clinical practice, they not suited for individualised radiotherapy. Objective, quantitative measurements of RILD on a continuous instead ordinal, semi-quantitative, semi-subjective scale, needed. Methods. Hounsfield unit (HU) changes before versus three months post-radiotherapy were correlated per voxel with radiotherapy 95 cancer patients. Deformable registration was to register pre- and post-CT scans density increase quantified various bins. The dose-response curve increased HU using slope linear regression (HU/Gy). end-point toxicity analysis dyspnoea ≥ grade 2. Results. Radiation linearly change (mean R2 = 0.74 ± 0.28). No differences HU/Gy between groups treated stereotactic radiotherapy, conventional radioth...