Highly Water-Dispersible, Highly Conductive, and Biocompatible Polypyrrole-Coated Silica Particles Stabilized and Doped by Chondroitin Sulfate

摘要: Currently available methods to prepare conducting polymers-coated colloidal substrates for biomedical applications need be improved because they involve the use of toxic reagents and tend result in aggregated products with diminished conductivity. The work herein describes first time a facile strategy preparing highly water-dispersible, conductive, biocompatible polypyrrole-coated silica core–shell (SiO2@PPy) particles using only chondroitin sulfate (CS), biologically derived polymer, as stabilizer dopant. CS preadsorbed onto surface serves template control confined growth PPy shell doping situ polymerized shell. thickness can tuned from 8 17 nm by varying amount. Increasing adsorbed layer deposition thinner shells on an SiO2 core provide water-dispersible SiO2@PPy particles. Moreover, CS-doped exhibit conductivities high 5.3 S cm−1. conductivity depends mass loading level Furthermore, good biocompatibility therefore have potential biomedicine.