Cooperative N-heterocyclic carbene Au and amino catalysis for continuous synthesis of secondary propargylamines in a fiber supported hydrophilic microenvironment

摘要: Abstract A series of reusable and tunable polyacrylonitrile fiber supported catalysts that make use the cooperative interplay between N-heterocyclic carbene (NHC) Au(III) amino groups have been developed for synthesis secondary propargylamines. The yield using immobilized NHC-Au(III) as catalyst is twice much its small molecule counterpart. Moreover, implementation a flow system with leads to short retention time 3.3 min an efficient productivity 27 mmol/h. highly catalytic activity this ascribed unique hydrophilic microenvironment consisting NHC-Au(III), -NH2 -CN in surface catalyst. In microenvironment, adjacent promote formation gold-acetylide complex cooperatively turnover numbers (TON) up 5200.