摘要: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for the treatment of pain and inflammation. Nonselective NSAIDs inhibit both cyclooxygenase (COX)-1 COX-2. Nephrotoxicity nonselective has been well documented. The effects selective COX-2 inhibitors on renal function blood pressure attracting increasing attention. In kidney, is constitutively expressed highly regulated in response to alterations intravascular volume. metabolites have implicated mediation renin release, regulation sodium excretion, maintenance flow. Similar NSAIDs, inhibition may cause edema modest elevations a minority subjects. also exacerbate preexisting hypertension or interfere with other antihypertensive drugs. Occasional acute failure reported. Caution should be taken when prescribed, especially high-risk patients (including elderly volume depletion).
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