Coenzyme Q regulates the expression of essential genes of the pathogen- and xenobiotic-associated defense pathway in C. elegans.
作者： Alexandra Fischer , Petra Niklowitz , Thomas Menke , Frank Döring
DOI: 10.3164/JCBN.15-46
关键词:
摘要: Coenzyme Q (CoQ) is necessary for mitochondrial energy production and modulates the expression of genes that are important inflammatory processes, growth detoxification reactions. A cellular surveillance-activated defenses (cSADDs) pathway has been recently identified in C. elegans. The down-regulation components cSADDs initiates an aversion behavior nematode. Here we hypothesized CoQ regulates pathway. To verify this generated CoQ-deficient worms ("CoQ-free") performed whole-genome profiling. We found about 30% (120 genes) were differentially regulated under condition. Remarkably, 83% these down-regulated. majority CoQ-sensitive encode proteins involved larval development (enrichment score (ES) = 38.0, p = 5.0E(-37)), aminoacyl-tRNA biosynthesis, proteasome function (ES 8.2, p = 5.9E(-31)) mitochondria 3.4, p = 1.7E(-5)). 67% (80 categorized as lethal. Thus it shown first time a substantial number essential evolutionary conserved
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