Fabrication and optimization of methylphenoxy substituted polyphosphazene nanofibers for biomedical applications.

摘要: Electrospinning has developed as a unique and versatile process to fabricate ultrathin fibers in the form of nonwoven meshes or oriented arrays from variety polymers. The very small dimension these can generate high surface area, which makes them potential candidates for various biomedical industrial applications. objective present study was develop nanofibers polyphosphazenes, class inorganic-organic polymers known biocompatibility, high-temperature stability, low-temperature flexibility. Specifically, we evaluated feasibility developing bead-free nanofiber mesh poly[bis(p-methylphenoxy)phosphazene] (PNmPh) by electrospinning. effect parameters such nature solvent, concentration polymer solution, needle diameter, applied on diameter morphology (beaded bead-free) resulting were investigated. It found that solution PNmPh chloroform at range 7% (wt/v) 9% be readily electrospun room temperature. mean obtained under optimized spinning condition approximately 1.2 microm. bead-free, cylindrical formed showed slightly irregular topography with indentations few nanometer scale. Further, mats supported adhesion bovine coronary artery endothelial cells (BCAEC) well promoted proliferation osteoblast like MC3T3-E1 cells.