Metallo-β-lactamase-producing Enterobacteriaceae isolates at a Taiwanese hospital: lack of distinctive phenotypes for screening

摘要: Liao I-C, Chen H-M, Wu J-J, Tsai P-F, Wang L-R, Yan J-J. Metallo-β-lactamase-producing Enterobacteriaceae isolates at a Taiwanese hospital: lack of distinctive phenotypes for screening. APMIS 2011; 119: 543–50. We investigated the prevalence metallo-β-lactamases (MBLs) among 1,827 collected in 2006 and evaluated VITEK 2 microbiology system, modified Hodge test, combined disk tests as screening tools MBLs by using these 77 previously characterized IMP-8 producers. The MBL was identified 18 2006, IMP-8-positive represented 0.2%, 1.1%, 5.0% all Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae isolates, respectively. Only one-third producers could be recognized either or test. production 38 (40%) 95 IMP-8-producing test meropenem disks supplemented phenylboronic acid EDTA, only (2.1%) gave positive results with dipicolinic acid. Of producers, 37.9%, 50.5%, 32.6% were nonsusceptible to tigecycline, fluoroquinolones, both, In conclusion, this study demonstrated distinct that easily hospital. Continuous surveillance monitoring are needed because widespread tigecycline- fluoroquinolone-coresistant may become serious therapeutic problem.