Ikaros deficiency in host hematopoietic cells separates GVL from GVHD after experimental allogeneic hematopoietic cell transplantation
作者： Tomomi Toubai , Hou Guoqing , Corrine Rossi , Nathan Mathewson , Katherine Oravecz-Wilson
DOI: 10.1080/2162402X.2015.1016699
关键词:
摘要: The graft-versus-leukemia (GVL) effect following allogeneic hematopoietic stem cell transplantation (allo-HCT) is critical for its curative potential. Hwever, GVL tightly linked to graft-versus-host disease (GVHD). Among hematological malignancies, acute lymphoblastic leukemia (ALL) the most resistant GVL, although reasons this remain poorly understood. Clinical studies have identified alterations in Ikaros (Ik) transcription factor as major marker associated with poor outcomes ALL. We shown that absence of Ik professional host-derived antigen-presenting cells (APCs) exacerbates GVHD. However, whether expression plays a role resistance not known. In study we used multiple clinically relevant murine models allo-HCT explore APCs and/or leukemic increasing and thus inducing relapse. found deficiency host failed enhance despite in...
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