NRP1 promotes cell migration and invasion and serves as a therapeutic target in nasopharyngeal carcinoma

作者: Chun Cheng , Zhaohao Huang , Bufan Xiao , Kaddie Kwok Chen , Yi Sang

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摘要: Neuropilin 1 (NRP1) promotes tumor growth, angiogenesis, migration, and invasion. Its higher expression is closely related to the metastasis poor outcome of many cancers. We have reported that NRP1 was expressed at levels in highly metastatic cells comparison minimally nasopharyngeal carcinoma (NPC). However, role NPC cell migration invasion still unclear, whether it could serve as a potential therapeutic target for patients with needs further investigation. In this study, our results demonstrated ectopic S26 6-10B promoted via wound healing transwell assays. contrast, knockdown HONE1, CNE1 S18 through Clustered Regularly Interspaced Short Palindromic Repeats interference (CRISPRi) technology suppressed Moreover, we found EG00229, small molecule inhibitor NRP1, significantly NRP1-mediated promotion Mechanistically, by decreasing E-cadherin increasing N-cadherin levels. Collectively, showed function promising future treatment NPC.

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