作者: Aram Keywan , Haike Dietrich , Max Wuehr , None
DOI: 10.1016/J.NEUROSCIENCE.2020.05.053
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摘要: Abstract Animal studies suggest that the vestibular system autoregulates its sensitivity in response to prolonged low- or high-intensity motion order maintain an optimal working range. In humans, corresponding attenuations of responses after exposure have been demonstrated. Here we explored whether a complementary increase human can be induced by conditioning at low-intensity, subliminal amplitudes. 9 healthy subjects, perceptual thresholds for translational along inter-aural (IA) axis were determined direction-recognition task baseline as well immediately and 20-min stimulation. The stimulus consisted 1 Hz sinusoidal IA translation amplitude 70% each subject’s threshold (2.09 ± 0.78 cm/s2 peak acceleration). second set experiments, tested also influences yaw rotations. Immediately conditioning, effectively lowered (p = 0.002; mean reduction: 28.8 ± 4.5%). These improvements transient had returned level 20 min (p = 0.015). Vestibular rotations remained on average unaltered indicating sensitizing effects might selective end-organ-specific pathways being stimulated during conditioning. findings demonstrate enhanced sensory similar observed other modalities. Conditioning-induced sensitization may effective treatment decrements elderly patients with hypofunction.