Recent advances in the formulation of sphingolipid anticancer therapeutics
作者： Min-Koo Choi , Im-Sook Song
DOI: 10.1007/S40005-020-00475-Y
关键词:
摘要: The bioactive sphingolipids such as ceramide, sphingosine, and sphingosine-1-phosphate are of special interest key regulators cellular proliferation or apoptosis signaling. balance between ceramide is critical for the selection proliferative apoptotic signaling well therapeutic efficacy against cancer cells. A number drug candidates designed to regulate have been developed several (i.e., safingol, ABC294640, Sonepcizumab, fingolimod) under clinical investigation anti-cancer drugs. Various nanotherapeutic challenges combined with use anticancer drugs and/or phospholipid metabolism inhibitors short chain has investigated increase accumulation which acts molecules. Many sphingolipid-containing nanotherapeutics shown promising results treatments. These sphingolipid can include a synergistic combination ceramide-forming agents inhibitors. Sphingolipid could also be used treat multidrug-resistant cells sensitive
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