Bone metastases, general and clinical issues.

摘要: The skeleton is the most common organ for metastasis from solid tumours. Bone metastases pose significant diagnostic and clinical challenges represent an important cause of cancer-related morbidity. Without appropriate bone-directed therapy, many patients will be at high risk potentially debilitating skeletal-related events (SREs), such as pain, bone fractures, neurologic deficits hypercalcemia, severely impacting on patient's quality life. Because their incidence, impose demands health care resources. optimal management skeletal depends underlying biology disease, extent involvement, presence severity symptoms, availability effective systemic therapies life expectancy patient. This article discusses issues concerning diagnosis available treatment approaches based presentation involvement. Emphasis placed role external beam-radiotherapy a local mode palliation decompression epidural compression potential ablative approach through high-dose image-guided irradiation (IGRT) in presenting with oligometastatic disease.