Medical therapies for mood disorders alter the blood-brain barrier
作者： S. Preskorn , G. Irwin , S Simpson , D Friesen , J Rinne
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摘要: The effects of amitriptyline, lithium, and electroconvulsive shock on cerebral permeability blood flow were tested. These three treatments share in common (i) the ability to influence functional activity central adrenergic neurons by way release, reuptake, or metabolism norepinephrine (ii) therapeutic efficacy mood disturbances. Under control conditions, increases linealy with increasing arterial partial pressure carbon dioxide hence flow. All altered this relationship a manner consistent their effects. Amitriptyline potentiated increase whereas lithium blunted phenomenon. results support hypothesis that one function is regulation blood-brain barrier raise possibility related effect may underlie clinical usefulness such treatment.
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sciencemag.org参考文章(16)
S. H. Preskorn, B. K. Hartman, M. E. Raichle, L. W. Swanson, H. B. Clark, Central Adrenergic Regulation of Cerebral Microvascular Permeability and Blood Flow: Pharmacologic Evidence Advances in Experimental Medicine and Biology. ,vol. 131, pp. 127- 138 ,(1980) , 10.1007/978-1-4684-3752-2_11
Cerebral Blood Flow in Depression American Journal of Psychiatry. ,vol. 137, pp. 1449- 1450 ,(1980) , 10.1176/AJP.137.11.1449
Sheldon H. Preskorn, Boyd K. Hartman, H. Brent Clark, Long-term antidepressant treatment: Alterations in cerebral capillary permeability Psychopharmacology. ,vol. 70, pp. 1- 4 ,(1980) , 10.1007/BF00432362
ROSS J. BALDESSARINI, Drugs Five Years Later Annals of Internal Medicine. ,vol. 83, pp. 527- 533 ,(1975) , 10.7326/0003-4819-83-4-527
M. E. Raichle, B. K. Hartman, J. O. Eichling, L. G. Sharpe, Central noradrenergic regulation of cerebral blood flow and vascular permeability. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 3726- 3730 ,(1975) , 10.1073/PNAS.72.9.3726
B. K. Hartman, D. Zide, S. Udenfriend, The Use of Dopamine β-Hydroxylase as a Marker for the Central Noradrenergic Nervous System in Rat Brain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 2722- 2726 ,(1972) , 10.1073/PNAS.69.9.2722
D. W. Costain, A. R. Green, D. G. Grahame-Smith, Enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy. Psychopharmacology. ,vol. 61, pp. 167- 170 ,(1979) , 10.1007/BF00426732
J. J. Schildkraut, P. R. Draskoczy, P. S. Lo, Norepinephrine Pools in Rat Brain: Differences in Turnover Rates and Pathways of Metabolism Science. ,vol. 172, pp. 587- 589 ,(1971) , 10.1126/SCIENCE.172.3983.587
Michael H. Ebert, Effects of Electroconvulsive Seizures on Amine Metabolism in the Rat Brain Archives of General Psychiatry. ,vol. 29, pp. 397- 401 ,(1973) , 10.1001/ARCHPSYC.1973.04200030085013
R L Van Uitert, D E Levy, Regional brain blood flow in the conscious gerbil. Stroke. ,vol. 9, pp. 67- 72 ,(1978) , 10.1161/01.STR.9.1.67