A novel role for HNO in local and spreading vasodilatation in rat mesenteric resistance arteries.
作者： Kathryn H. Yuill , Polina Yarova , Barbara K. Kemp-Harper , Christopher J. Garland , Kim A. Dora
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摘要: Abstract Nitric oxide-mediated vasodilatation has previously been attributed to the uncharged form of molecule (NO•), but increasing evidence suggests that nitroxyl (HNO) may play a significant role in endothelium-dependent relaxation. The aim this study was investigate mechanisms underlying HNO-mediated phenylephrine pre-constricted pressurized (70 mmHg) mesenteric arteries, and on membrane currents isolated smooth muscle cells using whole cell perforated patch clamp recordings. Angeli's salt (AS: donor), evoked concentration-dependent insensitive NO• scavengers carboxy-PTIO hydroxocobalamin (HXC), sensitive either HNO scavenger L-cysteine, K-channel blockers (4-AP iberiotoxin), raised [K+]o, or inhibition soluble guanylyl cyclase (ODQ). AS-evoked hyperpolarization significantly augmented KV current an ODQ manner, also increased BKCa current. Importantly, 30 μM AS initia...
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