Transmucosal dosage form

摘要: Compositions and methods of manufacture for producing a medicament composition capable absorption through the mucosal tissues mouth, pharynx, esophagus. The present invention relates to such compositions which are useful in administering lipophilic nonlipophilic drugs dose-to-effect manner that sufficient drug is administered produce precisely desired effect. also manufacturing techniques enable therapeutic agents (30) be incorporated into nondissolvable containment matrixes (34) releasing within patient's mouth. An appliance or holder (36) preferably attached matrix (34). Employing may introduced bloodstream almost as fast injection, much faster than using oral administration route, while avoiding negative aspects both these methods. include permeation enhancers increase by pH buffering modify salival thereby increasing tissues.