Functional Unfolded Proteins: How, When, Where, and Why?

摘要: Recent advances in the sequencing of whole genomes have given fascinating insights into overall composition encoded proteins. Many amino acid sequences that been deduced this way highly biased and are predicted to be unfolded. A significant number these correspond parts functional proteins, a surprising cases, unstructured regions most relevant protein for function – actual sites binding activators, repressors, other ligands. This is particularly true proteins involved signaling networks is, signal transduction, transcriptional activation, translation, cell cycle regulation. The intrinsically disordered facilitate interactions with multiple partners also provide means efficiently dissociating complex after has transduced. article briefly reviews some recent experimental evidence from our own labs, upon which conclusions based.