Effect of 1-year, low-dose DHEA therapy on climacteric symptoms and female sexuality

摘要: Background Sexual desire is affected by endocrine and psychosocial factors. Menopausal hormonal changes are relevant to the causes of sexual dysfunction during reproductive aging. Aim To evaluate effects different types replacement therapy (HRT) on function, frequency intercourse, quality relationship in early postmenopausal women. We recruited 48 healthy women aged 50 ‐ 60 years (mean age 54.5 � 3.3 years). Women with climacteric symptoms were uniformly randomized into three groups receiving either dehydroepiandrosterone (DHEA 10 mg) daily, or daily oral estradiol (1 plus dihydrogesterone (5 mg), tibolone (2.5 for 12 months. who refused treated vitamin D (400 IU). Effi cacy was evaluated using McCoy Female Sexuality Questionnaire before treatment after profi le 3, 6 Results The DHEA HRT reported a signifi cant improvement function compared baseline ( p 0.001 0.01, respectively) total score. similar at months treatment. There increases numbers episodes intercourse previous 4 weeks DHEA, comparison value 0.05, respectively). No score occurred D. Conclusions Daily dose mg, all provided