The α-endomannosidase gene ( MANEA ) is associated with panic disorder and social anxiety disorder

摘要: Unbiased genome-wide approaches can provide novel insights into the biological pathways that are important for human behavior and psychiatric disorder risk. The association of α-endomannosidase gene (MANEA) variants cocaine-induced paranoia (CIP) was initially described in a study used whole-genome approach. Behavioral effects have been reported other mannosidase genes, but MANEA function humans clinical potential previous findings remain unclear. We hypothesized would be associated with phenotypes unrelated to cocaine use. multi-stage approach starting four disorders show an between single-nucleotide polymorphism (SNP; rs1133503) anxiety disorders. In first 2073 European American (EA) 2459 African subjects mostly comorbid drug or alcohol dependence, we observed EAs rs1133503 panic (PD) (191 PD cases, odds ratio (OR)=1.7 (95% confidence interval (CI): 1.22–2.41), P=0.002). replicated this finding independent sample 142 cases (OR =1.53 CI: 1.00–2.31), P=0.043) extended it 131 generalized social (OR=2.15 1.27–3.64), P=0.004). alleles genotypes were also expression differences whole blood cells. Using publically available data, consistent effect on brain tissue. conclude involving warrant further investigation relation