Clinical Risk Factors for Complicated Disease: How Reliable Are They?

摘要: Crohn's disease is a chronic, progressive, destructive disease. Complicated can be defined as the presence of bowel damage (stricture, abscess or fistula) and/or need for surgery. Natural history studies provide invaluable data on course. In population-based cohorts, half all patients experienced an intestinal complication within 20 years after diagnosis and required surgery 10 diagnosis. Olmsted County, factors associated with development complications were ileal involvement perianal The extent noncolonic disease, current smoking, male gender, penetrating behavior early steroid use significantly major abdominal Overall, using various definitions complicated predictors worse outcome in were: extensive small severe upper gastrointestinal rectal lesions, stricturing/penetrating smoking young age at Aggressive ulcerative colitis was recently that high relapse rate, surgery, colon cancer extraintestinal manifestations. About one tenth still require colectomy 5 era biologics. An average 1.6% diagnosed colorectal during 14 follow-up cohorts. A younger pancolitis colitis. identification clinical risk may used future disease-modification trials.