Significant sequelae after bacterial meningitis in Niger: a cohort study

作者: Jean-François Jusot , Zilahatou Tohon , Abdoul Aziz Yazi , Jean-Marc Collard

DOI: 10.1186/1471-2334-13-228

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摘要: Background: Beside high mortality, acute bacterial meningitis may lead to a frequency of neuropsychological sequelae. The Sahelian countries belonging the belt experience approximately 50% cases occurring in world. Studies Africa have shown that N. meningitidis could cause hearing loss up 30% cases, exceeding sometimes measles. situation is similar Niger which experiences yearly epidemics and where rehabilitation wards are rare aids remain unaffordable. aim this study was estimate sequelae after four eight regions Niger. Methods: Subjects exposed were enrolled into cohort with non subjects matched on age gender. Consenting interviewed during inclusion at control visit two months later. If clinical symptoms or psychological troubles persisted both visits among significantly greater than observed subjects, retained. comparison between also calculated using Fisher exact test. Results: Three persisting functional registered: headaches, asthenia, vertigo 31.3, 36.9, 22.4% respectively subjects. A significant motor impairment retrieved 12.3% versus 1.6% Hearing disabled 31.3% 10.4% exhibited serious deafness. Conclusions: This carried out confirms neurological frequencies meningitis: severe profound impairment. Cochlear implantation too expensive for populations living developing countries. Neurological should sensitize African public health authorities development centers. All these challenges can be met through existing strategies guidelines.

参考文章(33)
Q Gopen, S N Merchant, A human temporal bone study of acute bacterial meningogenic labyrinthitis. American Journal of Otology. ,vol. 17, pp. 375- 385 ,(1996)
T. Deonna, M. L. Dutoit-Marco, C. Gander, P. A. Despland, J. Lütschg, H. Vienny, Early diagnosis and evolution of deafness in childhood bacterial meningitis: a study using brainstem auditory evoked potentials. Pediatrics. ,vol. 73, pp. 579- 586 ,(1984)
Brian Greenwood, Manson Lecture. Meningococcal meningitis in Africa. Transactions of The Royal Society of Tropical Medicine and Hygiene. ,vol. 93, pp. 341- 353 ,(1999) , 10.1016/S0035-9203(99)90106-2
Hope Forsyth, Fanny Kalumbi, Ethel Mphaka, Madalitso Tembo, James Mwenechanya, Kondowani Kayira, Loyd Bwanaisa, Alfred Njobvu, Amanda Walsh, Elisabeth Molyneux, Hearing loss in Malawian children after bacterial meningitis: incidence and risk factors Audiological Medicine. ,vol. 2, pp. 100- 107 ,(2004) , 10.1080/16513860410033711
Rianne Oostenbrink, Mariëlle Maas, Karel G. M. Moons, Henriëtte A. Moll, Sequelae after Bacterial Meningitis in Childhood Scandinavian Journal of Infectious Diseases. ,vol. 34, pp. 379- 382 ,(2002) , 10.1080/00365540110080179
K. M. Kuntz, E. K. MD, J. C. Stevens, P. M. RN, K. P. Offord, M. M. Ho, Post-lumbar puncture headaches: experience in 501 consecutive procedures. Neurology. ,vol. 42, pp. 1884- 1887 ,(1992) , 10.1212/WNL.42.10.1884
Jean-Marc Collard, Zaneidou Maman, Harouna Yacouba, Saacou Djibo, Pierre Nicolas, Jean-François Jusot, Jocelyne Rocourt, Rabi Maitournam, Increase in Neisseria meningitidis serogroup W135, Niger, 2010. Emerging Infectious Diseases. ,vol. 16, pp. 1496- 1498 ,(2010) , 10.3201/EID1609.100510
O.A. Lasisi, J.K. Ayodele, G.T.A. Ijaduola, Challenges in management of childhood sensorineural hearing loss in sub-Saharan Africa, Nigeria. International Journal of Pediatric Otorhinolaryngology. ,vol. 70, pp. 625- 629 ,(2006) , 10.1016/J.IJPORL.2005.08.009
Meenakshi Ramakrishnan, Aaron J Ulland, Laura C Steinhardt, Jennifer C Moïsi, Fred Were, Orin S Levine, Sequelae due to bacterial meningitis among African children: a systematic literature review BMC Medicine. ,vol. 7, pp. 47- 47 ,(2009) , 10.1186/1741-7015-7-47