Experimental Demonstration of DNA Hybridization Using Graphene Based Plasmonic Sensor Chip
作者： Jitendra Bahadur Maurya , Yogendra K. Prajapati
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摘要: Parvovirus B19 (B19V) and human bocavirus (HBoV) are notable dangerous pathogens based on ssDNA, which cause infectious diseases. Although label-free molecular level quantification of these is extremely challenging, it can be achieved by trending surface plasmon resonance (SPR) sensor. Here, a graphene-based plasmonic chip, essential in the SPR sensor, developed for specific detection ssDNA pathogens. The absorption curves reveal that graphene has significantly stronger interaction with than metal due to π-stacking bonding carbon rings nucleobases present ssDNA. Further, reflectance show shift angle more twice without even very low concentration, i.e., 0.23 μM target Additionally, penetration depth electric field sensing medium 2.5 times metal, silver, makes suitable comparatively larger molecules. combination extraordinary chemical optical properties represents highly sensitive DNA hybridization. It provides confident track diagnosis
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