Propofol reduces early post‐operative pain after gynecological laparoscopy

摘要: Background There is some evidence that propofol may reduce post-operative pain. However, the results on analgesic effects of are inconsistent. Thus, we hypothesized reduces acute pain if confounding factors like opioids avoided. Methods In this prospective, randomized, subject- and assessor-blind, parallel-group, head-to-head comparative study, 90 American Society Anesthesiologists I or II females underwent elective laparoscopies were randomized to receive either propofol-based (PR), sevoflurane-based (SR), sevoflurane-propofol-based anesthesia (SPR). Pain score at rest assessed by a numerical rating scale 0.5 h after surgery was primary outcome. The secondary outcomes included 1 24 h post-operatively, duration post-anesthesia care units stay (PACU), incidence nausea vomiting, shivering, quality recovery (QoR-40) within first post-operatively. Results No patients received rescue analgesia. post-operatively less in group PR when compared with SR (0.7 ± 1.4 vs. 2.1 ± 1.8; P = 0.010) SPR 2.1 ± 2.2; P = 0.008). Group also associated shorter PACU than (21.8 ± 5.7 26.2 ± 6.9; P = 0.050) 27.8 ± 8.9; P = 0.005). Intraoperative bispectral index values, hemodynamic values QoR-40 scores did not differ among three groups. Conclusions Propofol significantly 0.5 1 h undergoing gynecological planned opioid-free