Effects of adrenalectomy on hormone action on hepatic glucose metabolism. Impaired glucagon activation of glycogen phosphorylase in hepatocytes from adrenalectomized rats.
作者： T.M. Chan , K.E. Steiner , J.H. Exton
DOI: 10.1016/S0021-9258(19)86496-7
关键词:
摘要: Abstract The effects of adrenalectomy on glucagon activation liver glycogen phosphorylase and glycogenolysis were studied in isolated hepatocytes. Adrenalectomy resulted reduced responsiveness to activation. Stimulation cAMP accumulation cAMP-dependent protein kinase activity by was unaltered cells from adrenalectomized rats. did not alter the proportion type I II isozymes liver, whereas this changed fasting. Activation hepatocytes rats, although half-maximal effective concentration unchanged. No difference phosphatase between control rats detected. Glucagon-activated declined rapidly time course increase response normal. Addition glucose (15 mM) inactivated glucagon-stimulated both rat inactivation reversed increasing but accelerated It is concluded that impaired contributes stimulation hepatic possible role changes discussed.
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