Evaluation of a Long-Acting Opioid Restriction Policy: Does Restriction Reduce the Need for Naloxone Reversal?:

摘要: Purpose: After a sentinel event related to long-acting (LA) opioid administration at our institution and subsequent root cause analysis, an inpatient LA restriction policy was implemented improve patient safety. The objectives of this study were evaluate the effect on therapy utilization compare rates naloxone reversal events among patients administered opioids before after implementation. Methods: To first objective, electronic medical record report created capture all orders prescribed adults between March 1, 2014, July 30, 2017. Utilization compared implementation use controlled for by days. second administrations identified via query Naloxone independently evaluated 2 trained reviewers, third when discrepancies existed. Rates pre- post-policy phase. Results: results objective demonstrate that associated with statistically significant reduction in sustained throughout duration. For 144 deemed have opioid-related event, 12 (18.9%) pre-policy phase 17 (15.9%) This difference not (odds ratio [OR] = 1.629, confidence interval [CI] 0.711-3.732, P .248). Conclusion: A significantly reduced institution. Despite this, we did find reversals opioids. Further is warranted identify optimal method reduce toxicity.