Beta-globin gene cluster haplotypes in Venezuelan sickle cell patients from the State of Aragua
作者： Nancy Moreno , José A Martínez , Zorella Blanco , Leidys Osorio , Patrick Hackshaw
DOI: 10.1590/S1415-47572002000100005
关键词:
摘要: Seven polymorphic sites in the b-globin gene cluster were analyzed on a sample of 96 chromosomes Venezuelan sickle cell patients from State Aragua. The Benin haplotype was predominant with frequency 0.479, followed by Bantu (0.406); minority cases other haplotypes also identified: atypical A2 (0.042), Senegal (0.031), A7 (0.021) and Saudi Arabia/Indian haplotypes; however, Cameroon not identified this study. Our results are agreement historical records that establish Sudanese origins for African slaves brought into Venezuela.
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