Towards bone replacement materials from calcium phosphates via rapid prototyping and ceramic gelcasting
作者： A. Woesz , M. Rumpler , J. Stampfl , F. Varga , N. Fratzl-Zelman
DOI: 10.1016/J.MSEC.2005.01.014
关键词:
摘要: Abstract Biomimetic porous scaffolds made of calcium phosphate mineral are promising structures to develop bone replacement materials. In order fabricate with a strut size 450 μm, we used stereolithographic technique which selectively polymerises photosensitive liquid resin by visible light produce casting moulds for ceramic gelcasting. These were filled water based thermosetting slurry solidifies inside the mould. After burning mould and sintering, hydroxylapatite designed, fully interconnected macroporosity obtained. The preosteoblastic cell line MC3T3-E1, derived from mouse calvariae, was test biocompatibility in culture experiments. cells seeded on immersed medium cultured 2 weeks. Thereafter scaffold fixed investigated histological methods. osteoblast-like found cover whole external internal surface scaffold, they embedded collagenous extracellular matrix. had particular tendency fill any crack or opening generally smooth exposed surfaces.
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