Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L- RNA/ L- DNA aptamer
作者： Laure Yatime , Christian Maasch , Kai Hoehlig , Sven Klussmann , Gregers R. Andersen
DOI: 10.1038/NCOMMS7481
关键词:
摘要: Spiegelmers are mirror-image oligonucleotide aptamers designed for therapeutic use. Here the authors describe crystal structure of mixed L-RNA/L-DNA Spiegelmer NOX-D20 bound to complement component C5a, a key mediator innate immune response and clinical target in acute chronic inflammatory disorders.
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