Development of a Gene Therapy Trial for Metastatic Prostate Cancer
作者： Thomas A. Gardner
DOI: 10.21236/ADA473358
关键词:
摘要: Abstract : This award was to support the infrastructure and development of a Phase I clinical trial for men with metastatic prostate cancer. The under employs restricted replicative adenovirus (PRRA) excellent preclinical performance in vitro vivo relevant animal models human Several components statement work this have been completed. key component PRRA AdIU1 required slight modification before proceeding implementation as submitted. Reconfirmation activity modified prior moving forward trial. A majority funding from remains CTDA account no cost extension has requested allow continued trail order apply 2007 DOD Clinical Trial Award initiate 2008. Currently team place verified regulatory applications on hold can be filed.
sci-hub.st 参考文章(58)
L C Pan, P A Price, The effect of transcriptional inhibitors on the bone gamma-carboxyglutamic acid protein response to 1,25-dihydroxyvitamin D3 in osteosarcoma cells. Journal of Biological Chemistry. ,vol. 259, pp. 5844- 5847 ,(1984) , 10.1016/S0021-9258(18)91092-6
Eric R. Schuur, Daniel R. Henderson, Ronald Rodriguez, Jonathan W. Simons, Gail A. Henderson, Ho Yeong Lim, Prostate Attenuated Replication Competent Adenovirus (ARCA) CN706: A Selective Cytotoxic for Prostate-specific Antigen-positive Prostate Cancer Cells Cancer Research. ,vol. 57, pp. 2559- 2563 ,(1997)
J. Cheon, H.K. Kim, D.G. Moon, D.K. Yoon, J.H. Cho, S.K. Koh, Adenovirus-mediated suicide-gene therapy using the herpes simplex virus thymidine kinase gene in cell and animal models of human prostate cancer: changes in tumour cell proliferative activity. BJUI. ,vol. 85, pp. 759- 766 ,(2001) , 10.1046/J.1464-410X.2000.00516.X
A. M. DeMarzo, T. L. DeWeese, B. Mikhak, M. Goemann, Ronald Rodriguez, W. G. Nelson, R. DeJong, J. W. Simons, M. A. Carducci, D. C. Yu, R. Drew, Y. Chen, U. Hamper, S. Piantadosi, H. Van der Poel, S. Li, N. Detorie, D. R. Henderson, T. Haulk, A phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Research. ,vol. 61, pp. 7464- 7472 ,(2001)
Svend O. Freytag, Kenneth R. Rogulski, Dell L. Paielli, David H. Kirn, Carla C. Heise, Jeff D. Gilbert, Kang Zhang, Jae Ho Kim, In Vivo Antitumor Activity of ONYX-015 Is Influenced by p53 Status and Is Augmented by Radiotherapy Cancer Research. ,vol. 60, pp. 1193- 1196 ,(2000)
Sadao Kamidono, Shigeji Matsubara, Chia-Ling Hsieh, Yoshitaka Wada, Thomas A. Gardner, Thomas A. Gardner, Leland W. K. Chung, Jay Y. Gillenwater, Moon-Soo Park, Haiyen E. Zhau, Masayuki Egawa, Chinghai Kao, Chinghai Kao, A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Research. ,vol. 61, pp. 6012- 6019 ,(2001)
Toshiro Shirakawa, Robert A. Sikes, Jun Cheon, Leland W.K. Chung, Akinobu Gotoh, Song Chu Ko, Chinghai Kao, Gerard Karsenty, Osteocalcin Promoter-based Toxic Gene Therapy for the Treatment of Osteosarcoma in Experimental Models Cancer Research. ,vol. 56, pp. 4614- 4619 ,(1996)
NOBUYUKI HINATA, TOSHIRO SHIRAKAWA, SHUJI TERAO, KAZUMASA GODA, KAZUSHI TANAKA, YUJI YAMADA, ISAO HARA, SADAO KAMIDONO, MASATO FUJISAWA, AKINOBU GOTOH, Progress report on phase I/II clinical trial of Ad-OC-TK plus VAL therapy for metastatic or locally recurrent prostate cancer: Initial experience at Kobe University. International Journal of Urology. ,vol. 13, pp. 834- 837 ,(2006) , 10.1111/J.1442-2042.2006.01418.X
Harald zur Hausen, Thomas Rothmann, Arnd Hengstermann, Noel J. Whitaker, Martin Scheffner, Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells Journal of Virology. ,vol. 72, pp. 9470- 9478 ,(1998) , 10.1128/JVI.72.12.9470-9478.1998
Svend O Freytag, Mark Khil, Hans Stricker, James Peabody, Mani Menon, Mariza DePeralta-Venturina, Daniel Nafziger, Jan Pegg, Dell Paielli, Steve Brown, Ken Barton, Mei Lu, Estuardo Aguilar-Cordova, Jae Ho Kim, None, Phase I Study of Replication-competent Adenovirus-mediated Double Suicide Gene Therapy for the Treatment of Locally Recurrent Prostate Cancer Cancer Research. ,vol. 62, pp. 4968- 4976 ,(2002)