Structural Characterization and Anti-Proliferation Activities Against Tumor Cells of an Arabinogalactan from Juniperus convallium.
作者： Beibei Li , Mengxue Dong , Ji De , Li Ye , Daofeng Chen
DOI: 10.3390/MOLECULES24101850
关键词:
摘要: As a hyperproliferative disorder, cancer has continued to be major public health challenge. In the present study, polysaccharide JC-PS1 was isolated and purified from Juniperus convallium. is heteropolysaccharide composed of Ara, Gal, GalA Rha with average molecular weight 280 kDa. Based on methylation 2D NMR analysis, elucidated as backbone →5)-α-Araf-(1→ →3,5)-α-Araf-(1→, three kinds branches attached O-3 position including β-GalpA-(1→3)-β-Galp-(1→, α-Araf-(1→3)-α-Rhap-(1→ α-Araf-(1→3)-β-Galp-(1→. Accordingly, atomic force microscopy showed linear filamentous structure small proportion branches. Furthermore, exhibited significant anti-proliferation activities against PANC-1, A431, MDA-MB-231, U118MG H1975 cells IC50 values 296.8, 477.9, 657.4, 686.7 862.1 μg/mL, respectively. This indicated that could potential therapeutic agent for treatment cancer.
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