A randomized study of carbenicillin plus cefamandole or tobramycin in the treatment of febrile episodes in cancer patients
作者： Gerald P. Bodey , Steven J. Ketchel , Victorio Rodriguez
DOI: 10.1016/0002-9343(79)90242-0
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摘要: Abstract Patients were randomly assigned to receive carbenicillin plus tobramycin by continuous infusion (C+T), cefamandole (C+CC) or intermittent (C+IC) during 490 febrile episodes. Carbenicillin was administered over 2 hours every 4 hours. The per cent of cures achieved the 235 documented infections 65 for C+CC, 57 C+IC and 54 C+T. Among those caused single gram-negative bacilli, C+CC produced a higher cure rate than C+T (74 versus 59 50 cent). significantly more effective among patients with persistent severe neutropenia 3 (65 21 cent, p=0.03). If infecting organism sensitive both antibiotics, 94 cent. only major toxicity azotemia which occurred 12 13 episodes, regardless antibiotic regimen. However, it often fevers unknown etiology (20 6 p
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