Correlation Between Severity of Oral Mucositis and Both Overall and Gut Acute GvHD After High Intensity Conditioning Hematopoietic Stem Cell Transplantation.

摘要: Abstract 3057 We conducted a study to examine potential associations between the maximum severity of oral mucositis (OM) and subsequent peak acute graft-versus-host disease (GVHD) within 100 days after hematopoietic cell transplantation (HCT). Patients Methods: The cohort included 1689 consecutive patients who received high-intensity conditioning for treatment hematological 1995 2011 had at least 2 medicine evaluations 5 15 HCT with related or unrelated allogeneic bone marrow growth factor-mobilized blood cells. Severity OM was assessed prospectively according Oral Mucositis Index (OMI) (Schubert, et al, 1984). This index scores mucosal changes (atrophy, erythema, pseudomembranous ulcerations) in 13 areas cavity. Acute GVHD graded previously described criteria (Leisenring, 2006). OMI were divided into quartiles (0–17, 18–25, 26–39, 40–89). Maximum total score, clinical features erythema ulceration considered as risk factor analysis. Survival estimated by Kaplan-Meier method. Cumulative incidences (CI) overall gut standard methods, treating death competing risk. Cox regression used estimate hazard ratios events occurring first HCT, adjusting other factors. Results: median age 40 (range, 0–67) years. Of patients, 426 (25%) males recipients female donors, 971 (57%) low (i.e., CML chronic phase, MDS/RA MDS/RARS, leukemia remission) 718 (43%) high (all others diagnoses). 1011 (60%), TBI-containing regimens, 1473 (90%) methotrexate calcineurin inhibitor prophylaxis, 866 (51%) marrow, 786 (47%) mobilized 651 (39%) HLA-matched 552 (33%) 479 (28%) HLA-mismatched donors. 0–17 429 18–25 418 (25%), 26–39 434 (26%) 40–89 408 (24%). 946 (56%) grades II-IV GVHD, 383 (23%) III-IV GVHD. 906 (54%) stage 1 224 (13%) 2–4 incidence rates are shown Table 1. Erythema feature that most correlated both (p Conclusion: propose oropharyngeal injury caused pretransplant regimen reflects tissue throughout gastrointestinal tract. Our results support hypothesis increases Disclosures: No relevant conflicts interest declare.