Proposal of a new scoring scheme for the diagnosis of noninvasive endocervical glandular lesions.

摘要: The differential diagnosis of endocervical glandular lesions can be very difficult, and the interobserver agreement on borderline cases low. We are proposing a new scoring system to aid in reproducibility noninvasive lesions. total 67 diagnostically difficult were independently reviewed by five pathologists. After completion first round review, consensus was reached for each lesion all participants. This used as reference diagnosis. According consensus, included 21 benign/reactive conditions, 7 dysplasias, 39 adenocarcinomas situ. During second assessed using scheme, according which separate scores from 0 3 given for: 1) nuclear atypia, 2) stratification, 3) sum mitoses/apoptoses (counted two most active glands, average number used). These three then added result score (0-3 = benign; 4-5 dysplasia; 6-9 adenocarcinoma situ). Complete between observers review seen 35 (52.2%), kappa 0.565. improved with use scheme: 52 (77.6%), 0.705. If benign dysplasia diagnostic categories combined, overall would 63 (94%), meaning that scheme affords accurate distinction situ lesser propose applying this improve agreement. will more consistency data series different institutions allow uniformity issue precursor