Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties

摘要: The unique magnetic properties of iron oxide nanoparticles have paved the way for various biomedical applications, such as resonance cellular imaging or magnetically induced therapeutic hyperthermia. Living cells interact with by internalizing them within intracellular acidic compartments. Although no acute toxicity has been reported up to now, mechanisms nanoparticle degradation environment are still unknown. In organism, long term integrity and physical state iron-based challenged homeostasis. this study, we monitored 7 nm sized maghemite in a medium mimicking environment. Magnetic three distinct surface coatings, currently evaluated MRI contrast agents, were shown exhibit different kinetics dissolution at an pH presence citrate chelating agent. Our assessment during revealed that properties, size distribution structure remaining nanocrystals identical those initial suspension. This result suggests model rapidly dissolved reservoir intact nanoparticles.