Pulmonary innate immune modulation in the pathogenesis of allergic asthma

摘要: Recent studies have shown that the innate immune response plays a significant role in adaptive asthma. However, controversy exists regarding whether activating substances such as particulate matter, and bacterial components lipopolysaccharide (LPS) protect against or potentiate allergic diseases. Our first sought to determine LPS at challenge phase of asthma affects response. Because is ubiquitously present ambient air, we determined repeated inhalation alone could modulate pulmonary environment, thereby affecting onset progression increasing emphasis being placed removal from home means attenuating severity, affect during clinically relevant model. Asthma was induced by sensitization cockroach allergens, with house dust extract (HDE) collected an asthmatic child. Depletion HDE resulted attenuation IgE, augmented Th1 Th2 cytokine production lung. The LPS-depleted also exacerbated airways hyper-reactivity (AHR), suggesting environment does not phenotype. We would cause transient state refractoriness further challenge, termed tolerance. Mice receiving two exposures were protected excessive inflammation through