Intraperitoneal “Belly Bath” Chemotherapy

摘要: Intracavitary chemotherapy represents an emerging application of new technology in pharmacokinetic modeling used attempt to deliver potentially more effective chemotherapy. The introduction chemotherapeutic agents into body cavities lined by serosal membranes is certainly not new, but the concepts and practice have evolved substantially. antineoplastic peritoneal space, for example, does just provide “topical” directly on tumor but, perhaps as important, there a consequential redistribution drug via systemic vasculature following absorption circulation. In this sense, at least 1 component intracavitary infusional nature, with longer exposure time compared bolus Thus, other techniques, direct delivery drugs cavity attempts improve efficacy therapy increasing local concentrations moderately active well slowly dividing cell cycle phase-specific drugs.