Antibody engineering for therapeutics.

作者: Leonard Presta

DOI: 10.1016/S0959-440X(03)00103-9

关键词:

摘要: With the acceptance of antibodies as therapeutics, a diversity engineered antibody forms have been created to improve their efficacy, including enhancing effector functions full-length antibodies, delivering toxins kill cells or cytokines in order stimulate immune system, and bispecific target multiple receptors. After years vitro investigation, many these are now moving into clinical trials showing promise. A potential new type function for that is, generation reactive oxygen species may effect inflammation bacterial killing, has elucidated. In addition, field expanded beyond concentration on immunoglobulin G include therapeutics.

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