Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication

摘要: Studies show evidence of longitudinal brain volume decreases in schizophrenia. We studied changes and their relation to symptom severity, level function, cognition, antipsychotic medication participants with schizophrenia control from a general population based birth cohort sample relatively long follow-up period almost decade. All members the Northern Finland Birth Cohort 1966 any psychotic disorder random not having psychosis were invited for MRI scan, clinical cognitive assessment during 1999-2001 at age 33-35 years. A was conducted 9 years later 2008-2010. Brain scans both time points obtained 33 71 participants. Regression models used examine whether predicted over time, changes. The mean annual whole reduction 0.69% schizophrenia, 0.49% controls (p = 0.003, adjusted gender, educational level, alcohol use weight gain). patients found especially temporal lobe periventricular area. Symptom functioning decline cognition associated amount (dose equivalent 100 mg daily chlorpromazine) loss 0.003 In this sample, continues after onset illness, medications may contribute these reductions.