Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination.

摘要: The rapid and dynamic activation of the innate immune system is achieved through complex signaling networks regulated by post-translational modifications modulating subcellular localization, activity, abundance molecules. Many constitutively expressed molecules are present in cell inactive forms, become functionally activated once they modified with ubiquitin, and, turn, inactivated removal same mark. Moreover, upon infection resolution a remodeling proteome needs to occur, ensuring induced response proteins prevent hyperactivation. This review discusses current knowledge on negative regulation pathways deubiquitinating enzymes, degradative ubiquitination. It focusses spatiotemporal deubiquitinase E3 ligase activities, mechanisms for re-establishing proteostasis, degradation immune-specific feedback vs. general protein quality control pathways.