Drug Dosing in Acute Renal Failure: The Role of Renal Replacement Therapy in Altering Drug Pharmacokinetics

摘要: The combination of multiple medical problems requiring complex drug therapy with rapidly changing organ functions that lead to pharmacokinetic alterations makes regimen design in the intensive care unit challenging. Acute renal failure leads even greater physiologic disturbances additional pharmacologic, nutritional, and dialytic support. A variety replacement modalities, both intermittent continuous, are used manage solute, volume, acid-base derangements patients acute failure. Renal therapies differ their impact on dosing. clinician must consider disease treatment if prescribing is be optimal. Principles solute removal reviewed concepts discussed. practical approach this setting described. Examples dose adjustments for continuous provided.