Sex and Gender Differences in Cardiovascular Drug Therapy

摘要: This chapter outlines sex differences in pharmacokinetics and pharmacodynamics of the most frequently used drugs cardiovascular diseases, e.g., coronary artery disease, hypertension, heart failure. Retrospective analysis previously published drug trials revealed marked efficacy adverse effects a number drugs. includes higher mortality among women taking digoxin for failure, more torsade de pointes arrhythmia QT prolonging cough with ACE inhibitors. Trends towards greater benefit and/or female animals have been observed some studies endothelin receptor antagonists, calcium channel blocker amlodipine, ACE-inhibitor ramipril aldosterone antagonist eplerenone. However, reproduction these results independent solid statistical evidence is still lacking. Some require particularly careful dose adaptation women: beta-blocker metoprolol, verapamil, loop-, thiazide diuretics. In conclusion, to be taken into account therapy women.