The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
作者： GL Lukacs , Xiu-Bao Chang , C Bear , N Kartner , A Mohamed
DOI: 10.1016/S0021-9258(20)80582-1
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摘要: … stability of the two proteins. In summary, our data suggest that after reaching the plasma … -type counterpart at 37 "C, possibly due to changes in its structure and stability, similar to …
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sci-hub.st 参考文章(36)
P.J. Thomas, P Shenbagamurthi, J Sondek, J.M. Hullihen, P.L. Pedersen, The cystic fibrosis transmembrane conductance regulator. Effects of the most common cystic fibrosis-causing mutation on the secondary structure and stability of a synthetic peptide Journal of Biological Chemistry. ,vol. 267, pp. 5727- 5730 ,(1992) , 10.1016/S0021-9258(18)42610-5
C.E. Bear, F. Duguay, A.L. Naismith, N. Kartner, J.W. Hanrahan, J.R. Riordan, Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene. Journal of Biological Chemistry. ,vol. 266, pp. 19142- 19145 ,(1991) , 10.1016/S0021-9258(18)54971-1
G.L. Lukacs, O.D. Rotstein, S. Grinstein, Determinants of the phagosomal pH in macrophages. In situ assessment of vacuolar H(+)-ATPase activity, counterion conductance, and H+ "leak". Journal of Biological Chemistry. ,vol. 266, pp. 24540- 24548 ,(1991) , 10.1016/S0021-9258(18)54263-0
G.L. Lukacs, X.B. Chang, N Kartner, O.D. Rotstein, J.R. Riordan, S Grinstein, The cystic fibrosis transmembrane regulator is present and functional in endosomes. Role as a determinant of endosomal pH. Journal of Biological Chemistry. ,vol. 267, pp. 14568- 14572 ,(1992) , 10.1016/S0021-9258(18)42078-9
R J Sargeant, M R Pâquet, Effect of insulin on the rates of synthesis and degradation of GLUT1 and GLUT4 glucose transporters in 3T3-L1 adipocytes Biochemical Journal. ,vol. 290, pp. 913- 919 ,(1993) , 10.1042/BJ2900913
Paul M. Quinton, Cystic fibrosis: a disease in electrolyte transport The FASEB Journal. ,vol. 4, pp. 2709- 2710 ,(1990) , 10.1096/FASEBJ.4.10.2197151
N. Bradbury, T Jilling, G Berta, E. Sorscher, R. Bridges, K. Kirk, Regulation of plasma membrane recycling by CFTR Science. ,vol. 256, pp. 530- 532 ,(1992) , 10.1126/SCIENCE.1373908
Johanna M Rommens, Michael C Iannuzzi, Bat-sheva Kerem, Mitchell L Drumm, Georg Melmer, Michael Dean, Richard Rozmahel, Jeffery L Cole, Dara Kennedy, Noriko Hidaka, Martha Zsiga, Manuel Buchwald, Lap-Chee Tsui, John R Riordan, Francis S Collins, Identification of the cystic fibrosis gene: chromosome walking and jumping Science. ,vol. 245, pp. 1059- 1065 ,(1989) , 10.1126/SCIENCE.2772657
Jackson B. Gibbs, Ras C-terminal processing enzymes—New drug targets? Cell. ,vol. 65, pp. 1- 4 ,(1991) , 10.1016/0092-8674(91)90352-Y
Michael J. Welsh, Matthew P. Anderson, Devra P. Rich, Herbert A. Berger, Gerene M. Denning, Lynda S. Ostedgaard, David N. Sheppard, Seng H. Cheng, Richard J. Gregory, Alan E. Smith, Cystic fibrosis transmembrane conductance regulator: A chloride channel with novel regulation Neuron. ,vol. 8, pp. 821- 829 ,(1992) , 10.1016/0896-6273(92)90196-K