Elastin-like polypeptides in drug delivery ☆
作者： José Carlos Rodríguez-Cabello , Francisco Javier Arias , Matilde Alonso Rodrigo , Alessandra Girotti
DOI: 10.1016/J.ADDR.2015.12.007
关键词:
摘要: The use of recombinant elastin-like materials, or recombinamers (ELRs), in drug-delivery applications is reviewed this work. Although ELRs were initially used similar ways to other, more conventional kinds polymeric carriers, their unique properties soon gave rise systems unparalleled functionality and efficiency, with the stimuli responsiveness ability self-assemble readily allowing creation advanced systems. However, nature likely most important factor that has driven current breakthrough ELR-based delivery Recombinant technology allows an unprecedented degree complexity macromolecular design synthesis. In addition, materials easily incorporate any functional domain present natural proteins. Therefore, can exhibit complex interactions both drug load tissues cells towards which directed. Selected examples, ranging from highly nanocarriers macrodepots, will be presented.
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sci-hub.se 参考文章(149)
José Carlos Rodríguez-Cabello, Alessandra Girotti, Artur Ribeiro, Francisco Javier Arias, Synthesis of genetically engineered protein polymers (recombinamers) as an example of advanced self-assembled smart materials. Methods of Molecular Biology. ,vol. 811, pp. 17- 38 ,(2012) , 10.1007/978-1-61779-388-2_2
Raul Machado, Paulo C. Bessa, Rui L. Reis, José Carlos Rodriguez-Cabello, Margarida Casal, Elastin-based nanoparticles for delivery of bone morphogenetic proteins. Methods of Molecular Biology. ,vol. 906, pp. 353- 363 ,(2012) , 10.1007/978-1-61779-953-2_29
Michael C. Koetting, Jonathan T. Peters, Stephanie D. Steichen, Nicholas A. Peppas, Stimulus-responsive hydrogels: Theory, modern advances, and applications Materials Science & Engineering R-reports. ,vol. 93, pp. 1- 49 ,(2015) , 10.1016/J.MSER.2015.04.001
Dan W. Urry, What Sustains Life?: Consilient Mechanisms for Protein-Based Machines and Materials ,(2006)
Robert Price, Azadeh Poursaid, Joseph Cappello, Hamidreza Ghandehari, In vivo evaluation of matrix metalloproteinase responsive silk-elastinlike protein polymers for cancer gene therapy. Journal of Controlled Release. ,vol. 213, pp. 96- 102 ,(2015) , 10.1016/J.JCONREL.2015.06.022
Biraja C. Dash, Dilip Thomas, Michael Monaghan, Oliver Carroll, Xizhe Chen, Kimberly Woodhouse, Timothy O'Brien, Abhay Pandit, An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia. Biomaterials. ,vol. 65, pp. 126- 139 ,(2015) , 10.1016/J.BIOMATERIALS.2015.06.037
Lalita Prasad-Reddy, Diana Isaacs, A clinical review of GLP-1 receptor agonists: efficacy and safety in diabetes and beyond. Drugs in context. ,vol. 4, pp. 212283- 212283 ,(2015) , 10.7573/DIC.212283
Haijuan Zou, Zhongjuan Wang, Min Feng, Nanocarriers with tunable surface properties to unblock bottlenecks in systemic drug and gene delivery Journal of Controlled Release. ,vol. 214, pp. 121- 133 ,(2015) , 10.1016/J.JCONREL.2015.07.014
Jayanta Bhattacharyya, Joseph J. Bellucci, Isaac Weitzhandler, Jonathan R. McDaniel, Ivan Spasojevic, Xinghai Li, Chao-Chieh Lin, Jen-Tsan Ashley Chi, Ashutosh Chilkoti, A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models Nature Communications. ,vol. 6, pp. 7939- 7939 ,(2015) , 10.1038/NCOMMS8939
Jindřich Kopeček, Swell gels Nature. ,vol. 417, pp. 389- 391 ,(2002) , 10.1038/417388A