摘要: Domains or modules known to bind phosphoinositides have increased dramatically in number over the past few years, and are found proteins involved intracellular trafficking, cellular signaling, cytoskeletal remodeling. Analysis of lipid binding by these domains its structural basis has provided significant insight into mechanism membrane recruitment different phosphoinositides. that target only rare (3-phosphorylated) must with very high affinity, exquisite specificity. This is achieved solely headgroup interactions case certain pleckstrin homology (PH) [which PtdIns(3,4,5)P3 and/or PtdIns(3,4)P2], but requires an additional membrane-insertion oligomerization component PtdIns(3)P-targeting phox (PX) FYVE domains. PtdIns(4,5)P2, which more abundant some 25-fold, do not require same stringent affinity specificity characteristics, tend be diverse structure. The mode phosphoinositide also appears reflect their distinct functions. For example, serve as simple targeting recognize headgroups. By contrast, other domains, notably epsin ENTH domain, appear promote bilayer curvature inserting upon binding.
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