Evidence for a moderating effect of drinking severity but not HIV status on brain age in heavy episodic drinkers

摘要: Abstract Background Chronic HIV infection and alcohol use have been associated with brain changes neurocognitive impairment. However, their combined effects are less well studied. We correlated measures of “brain age gap” (BAG) impairment in participants without HIV/AIDS heavy episodic drinking (HED). predicted that BAG will be greater PWH who engage HED these particularly pronounced frontoparietal subcortical regions. Method 69 were recruited from a community health centre Cape Town: HIV-/HED-(N = 17), HIV+/HED- (N 14), HIV-/HED+ 21), HIV+/HED+ 17). Brain gap was derived thickness, area volumetric measurements the whole or one six Linear regression models employed to identify differences between patient groups controls. Associations clinical indicators status also tested using bivariate statistical methods. Results Compared controls, observed (Cohen’s d 1.61, p Conclusion The association BAG, independent status, points importance screening for targeting disorders primary care. Our findings point utility assessing contribution regions BAG.