Synthetic analogs of growth hormone-releasing factor with antagonistic activity in vitro
作者： Kazuki Sato , Mari Hotta , Jingo Kageyama , Hsiao-Yu Hu , Ming-Hui Dong
DOI: 10.1016/0006-291X(90)91773-L
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摘要: Abstract Analogs of human and rat growth hormone-releasing factor (hGRF rGRF), related to [D-Arg 2 ]hGRF(1–29)NH , were synthesized by solid phase methodology. Their capacity inhibit hormone secretion stimulated hGRF(1–44)NH was tested on anterior pituitary cells in monolayer culture. Among the analogs hGRF, 2,29 ,Arg 30 ]hGRF(1–30)NH showed highest antagonistic potency 3.64 relative = 1. However, most potent analog thus far [N-Ac-His 1 D-Arg ,Ala 15 ]rGRF(1–29)NH which a 27.7.
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