Radiosensitization of E. coli B/r by 9-anilinoacridines.

摘要: Six anilinoacridine derivatives have been tested for the ability to act as radiosensitizers. Two gave good sensitization at concentrations of 100 microM or less. Both these are known possess significant activity against experimental tumours, and one (m-AMSA) is in Phase II clinical trial a chemotherapeutic drug. Anilinoacridines may potential drugs with both radiosensitizing role. In spite their structural similarity, 2 which sensitize do so by different mechanisms. Compound VI behaves like typical hypoxic cell sensitizer but I interferes accumulation sublethal damage either presence absence O2. The latter also displays post-irradiation sensitizing effect. Differences mechanism be related relative DNA-binding abilities electronic differences between drugs.