Doxorubicin-doxorubicin conjugate prodrug as drug self-delivery system for intracellular pH-triggered slow release.
作者： Jiagen Li , Xinming Li , Peng Liu
DOI: 10.1016/J.COLSURFB.2019.110608
关键词:
摘要: Drug content and releasing rate are the main determining factors for drug delivery systems (DDSs). Here, doxorubicin dimer (D-DOXcar) was synthesized as drug-drug conjugate prodrug with high of 86%, via an acid-triggered hydrolysable carbamate linker. The nanoparticles (D-DOXcar-NP) different diameters were prepared self-delivery system (DSDS) intracellular pH-triggered slow release. They showed size- concentration-dependent DOX For D-DOXcar-sNP smaller diameter, cumulative release ratio reached 25.6% at pH 5.0 within 60 h. MTT results demonstrated that proposed DSDS similar tumor inhibition regardless carboxylesterases, enhanced anti-tumor efficacy on HepG2 cells in comparison free DOX.
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