Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists
作者： Gregory J. Howard , Jennifer J. Schlezinger , Mark E. Hahn , Thomas F. Webster
DOI: 10.1289/EHP.0901312
关键词:
摘要: BackgroundPredicting the expected outcome of a combination exposure is critical to risk assessment. The toxic equivalency factor (TEF) approach used for analyzing joint effects dioxin-like chemi...
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sci-hub.se 参考文章(19)
Berenbaum Mc, What is synergy Pharmacological Reviews. ,vol. 41, pp. 93- 141 ,(1989)
F. R. Cassee, Josje H. E. Arts, John P. Groten, Victor J. Feron, Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats Archives of Toxicology. ,vol. 70, pp. 329- 337 ,(1996) , 10.1007/S002040050282
Jac M.M.J.G. Aarts, Michael S. Denison, Mary A. Cox, Marjolijn A.C. Schalk, Patricia M. Garrison, Kathryn Tullis, Laura H.J. de Haan, Abraham Brouwer, Species-specific antagonism of Ah receptor action by 2,2′,5,5′-tetrachloro- and 2,2′,3,3′,4,4′-hexachlorobiphenyl European Journal of Pharmacology: Environmental Toxicology and Pharmacology. ,vol. 293, pp. 463- 474 ,(1995) , 10.1016/0926-6917(95)90067-5
Stephen Safe, Limitations of the toxic equivalency factor approach for risk assessment of TCDD and related compounds Teratogenesis Carcinogenesis and Mutagenesis. ,vol. 17, pp. 285- 304 ,(1997) , 10.1002/(SICI)1520-6866(1997)17:4/5<285::AID-TCM11>3.0.CO;2-B
Michael S Denison, Alessandro Pandini, Scott R Nagy, Enoch P Baldwin, Laura Bonati, Ligand binding and activation of the Ah receptor Chemico-Biological Interactions. ,vol. 141, pp. 3- 24 ,(2002) , 10.1016/S0009-2797(02)00063-7
Andreas Kortenkamp, Ten Years of Mixing Cocktails: A Review of Combination Effects of Endocrine-Disrupting Chemicals Environmental Health Perspectives. ,vol. 115, pp. 98- 105 ,(2007) , 10.1289/EHP.9357
Elisabete Silva, Nissanka Rajapakse, Andreas Kortenkamp, Something from "nothing"--eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects. Environmental Science & Technology. ,vol. 36, pp. 1751- 1756 ,(2002) , 10.1021/ES0101227
Eli V. Hestermann, John J. Stegeman, Mark E. Hahn, Relative contributions of affinity and intrinsic efficacy to aryl hydrocarbon receptor ligand potency. Toxicology and Applied Pharmacology. ,vol. 168, pp. 160- 172 ,(2000) , 10.1006/TAAP.2000.9026
Hiroyoshi Toyoshiba, Nigel J Walker, A.John Bailer, Christopher J Portier, Evaluation of toxic equivalency factors for induction of cytochromes P450 CYP1A1 and CYP1A2 enzyme activity by dioxin-like compounds. Toxicology and Applied Pharmacology. ,vol. 194, pp. 156- 168 ,(2004) , 10.1016/J.TAAP.2003.09.015
H P Ciolino, G C Yeh, The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor. British Journal of Cancer. ,vol. 79, pp. 1340- 1346 ,(1999) , 10.1038/SJ.BJC.6690216