作者: Joan Fuchs , Katrin Faber , Daniel T. Tuchscherer , Dimitrios A. Tsakiris , Stefan Weiler
DOI: 10.1016/J.TOXICON.2020.04.002
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摘要: Bothrops venezuelensis is a venomous snake of the Viperidae family. It associated with high snakebite-related morbidity and mortality in Venezuela, although clinical case descriptions are scarce. Bites by other sp. can result coagulopathy acute kidney injury. We describe bite captive juvenile B. that caused local swelling, severe pain, endothelial damage, excessive fibrinolysis (INR >12, aPTT 136s, fibrinogen 0.3g/l) incoagulable blood within 1.5 hours after bite. The patient was treated prothrombin complex factors concentrate, antivenom (Antivipmyn®, Instituto Bioclon, Mexico) 4.5 h bite, which improved coagulation parameters progressively. Subsequently signs compensated disseminated intravascular manifested received fresh frozen plasma erythrocyte concentrate. developed injury macroscopic hematuria. Fluid overload resulted pulmonary edema requiring intermittent ventilation diuretic treatment furosemide. He discharged moderately elevated creatinine 16 days hospitalization. Creatinine level normalized another week. This displays life-threatening toxicity even bites comparability to